Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-kappa B and regulating Nrf2/HO-1 pathway

作者：Tuzcu Mehmet; Aslan Abdullah; Tuzcu Zeynep; Yabas Mehmet; Bahcecioglu Ibrahim Halil; Ozercan Ibrahim Hanifi; Kucuk Omer; Sahin Kazim^*

来源：Molecular Nutrition & Food Research, 2012, 56(9): 1477-1481.

DOI：10.1002/mnfr.201200130

• Colorectal cancer
• Cyclooxygenase-2
• NF-?B
• Oxidative stress
• Tomato powder

Cancer is one of the leading causes of death worldwide. Since dietary factors have been connected to a reduced risk of a diversity of human cancers, in this study we investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)-induced colorectal cancer in Wistar rats, and possible mechanism(s) by which TP shows its chemopreventive activity. Here we show that TP added to feed at 5% rate decreases the rate of aberrant crypt foci (ACF) and reduces the development of adenocarcinoma and growth of AOM-induced colorectal cancer in rats. In addition, we demonstrate that TP supplementation shows its chemopreventive activities through inhibition of cyclooxygenase-2 (COX-2) expression via NF-?B pathway and promotion of apoptosis, as well as regulating Nrf2/HO-1 signaling pathway in colorectal tissue of AOM-treated rats. Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats, and suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men.

• 出版日期2012-9