Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity

作者：Puerstinger Gerhard^*; Paeshuyse Jan; De Clercq Erik; Neyts Johan

来源：Bioorganic & Medicinal Chemistry Letters, 2007, 17(2): 390-393.

DOI：10.1016/j.bmcl.2006.10.039

• imidazo[4,5-c]pyridines
• BVDV inhibitor
• HCV inhibitor
• antiviral

A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) resulted in an analogue with selective activity against HCV in the subgenomic replicon system.

• 出版日期2007-1-15
• 单位河北医科大学