Anticandidal action of fungal chitosan against Candida albicans

作者：Tayel Ahmed A^*; Moussa Shaaban; El Tras Wael F; Knittel Dierk; Opwis Klaus; Schollmeyer Eckhard

来源：International Journal of Biological Macromolecules, 2010, 47(4): 454-457.

DOI：10.1016/j.ijbiomac.2010.06.011

• Antifungal
• Candidicidal action
• Microbial chitosan
• Natural biocides

The anticandidal activity of four fungal chitosan types, produced from Mucor rouxii DSM-1191, against three Candida albicans strains was determined. The most bioactive chitosan type, to inhibit C. albicans growth, had the lowest molecular weight (32 kDa) and the highest deacetylation degree (94%). Water soluble types had stronger anticandidal activity than soluble types in 1% acetic acid solution. Scanning electron micrographs of treated C. albicans with fungal chitosan proved that chitosan principally interact with yeast cell wall, causing severe swelling and asymmetric rough shapes, and subsequent cell wall lyses with the prolonging of exposure time. Fungal chitosan could be recommended for C. albicans control as a powerful and safe alternative to synthetic and chemical fungicides.

• 出版日期2010-11-1