Development of a combined broadband near-infrared and diffusion correlation system for monitoring cerebral blood flow and oxidative metabolism in preterm infants

作者：Diop Mamadou^*; Kishimoto Jessica; Toronov Vladislav; Lee David S C; Lawrence Keith St

来源：Biomedical Optics Express, 2015, 6(10): 3907-3918.

DOI：10.1364/BOE.6.003907

Neonatal neuromonitoring is a major clinical focus of nearinfrared spectroscopy (NIRS) and there is an increasing interest in measuring cerebral blood flow (CBF) and oxidative metabolism (CMRO2) in addition to the classic tissue oxygenation saturation (StO(2)). The purpose of this study was to assess the ability of broadband NIRS combined with diffusion correlation spectroscopy (DCS) to measured changes in StO(2), CBF and CMRO2 in preterm infants undergoing pharmaceutical treatment of patent ductus arteriosus. CBF was measured by both DCS and contrastenhanced NIRS for comparison. No significant difference in the treatmentinduced CBF decrease was found between DCS (27.9 +/- 2.2%) and NIRS (26.5 +/- 4.3%). A reduction in StO(2) (70.5 +/- 2.4% to 63.7 +/- 2.9%) was measured by broadband NIRS, reflecting the increase in oxygen extraction required to maintain CMRO2. This study demonstrates the applicability of broadband NIRS combined with DCS for neuromonitoring in this patient population.

• 出版日期2015-10-1