Adrenomedullin attenuates aortic cross-clamping induced myocardial injury in rats

作者：Oyar Eser Oz^*; Kiris Ilker; Gulmen Senol; Ceyhan Betul Mermi; Cure Medine Cumhur; Sutcu Recep; Lortlar Nese; Okutan Huseyin

来源：American Journal of Surgery, 2011, 201(2): 226-232.

DOI：10.1016/j.amjsurg.2010.04.011

• Adrenomedullin
• Abdominal aortic surgery
• Ischemia-reperfusion
• Myocardial injury
• Oxidative stress
• Caspase-3
• Endothelin-1
• Angiotensin II

BACKGROUND: In this study we investigate the effects of adrenomedullin on myocardial injury after ischemia-reperfusion (I/R) after abdominal aortic surgery.
METHODS: Thirty-two Wistar rats were randomized into 4 groups (n = 8) as follows: control group (sham laparotomy), the aortic I/R group, aortic I/R plus adrenomedullin group (underwent aortic I/R periods, and received a bolus intravenous injection of .05 mu g/kg/min adrenomedullin), and the control plus adrenomedullin group.
RESULTS: Biochemical analysis showed that aortic I/R significantly increased (P < .05) the plasma levels of troponin-I and tumor necrosis factor-a, and the myocardial tissue levels of malondialdehyde, superoxide dismutase, catalase, and angiotensin II, whereas aortic I/R plus adrenomedullin significantly decreased these same factors (P < .05). Aortic I/R significantly increased (P < .05) myocardial tissue levels of nitric oxide whereas aortic I/R plus adrenomedullin significantly increased the same factor (P < .05).
CONCLUSIONS: These results indicate that adrenomedullin has protective effects against myocardial injury induced by abdominal aortic I/R in rats.

• 出版日期2011-2