Highly bioavailable nanocalcium from oyster shell for preventing osteoporosis in rats

作者：Lee Yun Kyung; Jung Sung Keun; Chang Yoon Hyuk^*; Kwak Hae Soo^*

来源：International Journal of Food Sciences and Nutrition, 2017, 68(8): 931-940.

DOI：10.1080/09637486.2017.1307948

• Nanopowdered oyster shell
• bioavailability
• bone
• zinc
• osteoporosis

Oyster shell is one of the foremost natural sources of calcium and is used as an alternative treatment for osteoporosis. In this study, we demonstrated that zinc-activated nanopowdered oyster shell (Zn-NPOS) effectively reduced bone loss compared with powdered oyster shell (POS) in an ovariectomized rat (OVX) model. As a result of nanosizing, the solubility and bioavailability of the oyster shell were greatly improved, and its effectiveness was further enhanced by zinc activation. Bone analysis indicated greater recovery from ovariectomy-induced bone loss following Zn-NPOS treatment. Moreover, Zn-NPOS treatment resulted in higher bone strength and superior trabecular architecture compared with NPOS and POS treatments. Furthermore, Zn-NPOS showed greater efficiency in increasing bone formation and reducing bone resorption markers. Therefore, nanosizing with zinc activation could be a viable strategy for improving the efficiency of oyster shells used for osteoporosis prevention.

• 出版日期2017