Autoimmune and gastrointestinal dysfunctions: does a subset of children with autism reveal a broader connection?

作者：Brown Amy C^*; Mehl Madrona Lewis

来源：Expert Review of Gastroenterology and Hepatology, 2011, 5(4): 465-477.

DOI：10.1586/EGH.11.46

• abdominal distension
• autism
• autoimmune
• constipation
• diarrhea
• food allergy
• food sensitivity
• gastrointestinal
• genetic
• permeable gut

A large number of autoimmune disorders have a gastrointestinal (GI) dysfunction component that may interplay with genetic, hormonal, environmental and/or stress factors. This narrarive review investigates possible links between autism, immune system abnormalities and GI symptoms in a subgroup of children with autism. A literature search on Medline (1950 to September 2010) was conducted to identify relevant articles by using the keywords 'autism and gastrointestinal' (71 publications) and 'autism and immune' (237 publications), cross-referencing and general searching to evaluate the available literature on the immunological and GI aspects of autism. Sufficient evidence exists to support that a subgroup of children with autism may suffer from concomitant immune-related GI symptoms.

• 出版日期2011-7