A Neutron Dynamic Therapy with a Boron Tracedrug UTX-51 Using a Compact Neutron Generator

作者：Hori Hitoshi^*; Tada Ryu; Uto Yoshihiro; Nakata Eiji; Morii Takashi; Masuda Kai

来源：Anticancer Research, 2014, 34(8): 4557-4560.

• Neutron dynamic therapy
• NDT
• compact neutron generator
• boron tracedrug
• UTX-51
• curcuminoid

Background/Aim: We are developing a neutron dynamic therapy (NDT) with boron tracedrugs for a new mechanical-clearance treatment of pathotoxic misfolded, aggregated, and self-propagating prion-associated disease proteins. We present a compact neutron generator-based NDT using a boron tracedrug UTX-51. Our NDT is based on the weak thermal neutron-bombarded destructive action of UTX-51 on bovine serum albumin (BSA) using the neutron beams produced from a compact inertial electrostatic confinement fusion (IECF) neutron generator. Results: BSA as an NDT molecular target was subjected to thermal neutron irradiation for eight hours using a compact neutron generator. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis pattern showed no protein band when 2 nmoles of BSA were irradiated with more than 100 nmoles of UTX-51, while BSA was not affected when irradiated without UTX-51. Conclusion: For the first time, we have succeeded in the molecular destruction of a prion-disease model protein, BSA, by NDT with a boron tracedrug, UTX-51, using a compact neutron generator.

• 出版日期2014-8