Nickel-Catalyzed Allylic C(sp(3))-F Bond Activation of Trifluoromethyl Groups via beta-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

作者：Ichitsuka Tomohiro; Fujita Takeshi; Ichikawa Junji^*

来源：ACS Catalysis, 2015, 5(10): 5947-5950.

DOI：10.1021/acscatal.5b01463

• C-F bond activation
• nickel catalysis
• trifluoromethylalkenes
• alkynes
• 1,4-dienes
• beta-fluorine elimination

The nickel-catalyzed defluorinative coupling of 2-trifluoromethyl-1-alkenes and alkynes with the aid of Et3SiH provides 1,1-difluoro-1,4-dienes under mild reaction conditions. This reaction involves selective allylic C(sp(3))-F bond activation via beta-fluorine elimination from nickelacyclopentenes.

• 出版日期2015-10