AgBF4 catalyzed regio- and stereoselective synthesis of trans alpha-vinyl-beta-amino esters via asymmetric addition of siyl dienolate to sulfinylimines

作者：Liu, Yingle^*; Yang, Yi; Jiang, Yan

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191(7): 975-979.

DOI：10.1080/10426507.2015.1136308

• beta-Amino acids
• N-tert-butanesulfimine
• Mannich addition
• asymmetric

AgBF4 catalyzed Mannich-type reactions of siyl dienolate with chiral aryl-substituted (S)-N-tert-butanesulfinylimines has been developed. A class of chiral trans -vinyl--amino esters was obtained in moderate to excellent yields (up to 93%), good diastereoselectiveties (up to 92:8 dr), and complete -site regioselectivity.
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• 出版日期2016
• 单位四川轻化工大学