Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension

作者：Agafonova I G^*; Bogdanovich R N; Kolosova N G

来源：Bulletin of Experimental Biology and Medicine, 2015, 160(2): 223-227.

DOI：10.1007/s10517-015-3134-z

• arterial hypertension
• endothelial vasomotor function
• OXYS rats
• magnetic resonance tomography
• angiography

Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exerted a benevolent therapeutic effect in renal arteries: it decreased BP, diminished thrombus formation in fi ne capillaries and arterioles, demonstrated the anticoagulant properties, partially improved endothelial dysfunction of small renal arteries, and up-regulated the glomerular filtration.

• 出版日期2015-12