Anti-Infective Pregnane Steroid from the Octocoral Carijoa riisei Collected in South Brazil

作者：de Almeida Maria T R^*; Tonini Maiko L; Guimaraes Tatiana da R; Bianco Everson M; Moritz Maria I G; Oliveira Simone Q; Cabrera Gabriela M; Palermo Jorge A; Reginatto Flavio H; Steindel Mario; Schenkel Eloir P

来源：Latin American Journal of Pharmacy, 2012, 31(10): 1489-1495.

• Antiprotozoal
• Carijoa riisei
• Leishmania braziliensis
• Octocoral
• Pregnane sterol
• Trypanosoma cruzi

In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion method, and inhibited 43.4 and 35.9 % the growing of T. cruzi epimastigotes and L. braziliensis promastigotes, respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro antiprotozoal activity against the extracellular forms of the parasites at 50 mu M, showing 50.4 % growth inhibition of L. braziliensis and 42.4 % growth inhibition of T. cruzi.

• 出版日期2012-12