Vitamin D as a protective factor in multiple sclerosis

作者：Salzer Jonatan^*; Hallmans Goran; Nystrom Maria; Stenlund Hans; Wadell Goran; Sundstrom Peter

来源：Neurology, 2012, 79(21): 2140-2145.

DOI：10.1212/WNL.0b013e3182752ea8

Objective: To examine the association between 25-hydroxyvitamin D (25[OH] D) levels and the risk of multiple sclerosis (MS) in blood samples collected prospectively and during gestation. %26lt;br%26gt;Methods: In this nested case-control study, 2 population-based biobanks with 291,500 samples from 164,000 persons collected since 1975 in the northern half of Sweden were used. We identified prospectively collected blood samples from MS cases (n = 192, controls matched 2: 1) and gestational samples from pregnant mothers where the offspring had later developed MS (n 5 37, control mothers matched 5: 1). 25(OH) D levels were measured using an ELISA, and the risk of MS was analyzed using matched logistic regression. %26lt;br%26gt;Results: Levels of 25(OH) D %26gt; 75 (vs %26lt; 75) nmol/L in prospectively collected blood samples were associated with a decreased risk of MS (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.16-0.98). No decrease in MS risk was found in the offspring exposed to gestational 25(OH) D levels %26gt;= 75 (vs %26lt; 75) nmol/L (OR 1.8, 95% CI 0.53-5.8). The prevalence of 25(OH) D levels %26gt;= 75 nmol/L in female controls decreased gradually during 1976-2005 (p trend = 0.005). %26lt;br%26gt;Conclusion: This study supports the presence of an association between high 25(OH) D levels during the years preceding disease onset and a decreased risk of MS. In the very limited material with samples drawn in early pregnancy, where month-of-birth effects were controlled for, we found no association between gestational 25(OH)D levels and MS risk in the offspring. Decreasing 25(OH) D levels in the population may contribute to explain the increasing MS incidence that is suggested from epidemiologic studies. Neurology (R) 2012; 79: 2140-2145

• 出版日期2012-11