A Modular Synthesis of Highly Substituted Imidazolium Salts

作者：Hirano Keiichi; Urban Slawomir; Wang Congyang; Glorius Frank^*

来源：Organic Letters, 2009, 11(4): 1019-1022.

DOI：10.1021/ol8029609

A versatile and modular one-pot method for the preparation of differently substituted symmetrical and unsymmetrical imidazolium salts is reported, and 19 examples are given. In the key step, readily available formamidines and alpha-halo ketones are coupled to give imidazolinium salts 3, followed by imidazolium salt formation by acylation-induced elimination. For many substitution patterns of the imidazolium salt products, this efficient strategy compares favorably with well-known processes in terms of yield, ease of synthesis, and robustness.

• 出版日期2009-2-19