A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy

作者：Liu, Ya; Zhang, Di; Qiao, Zeng-Ying; Qi, Guo-Bin; Liang, Xing-Jie; Chen, Xi-Guang^*; Wang, Hao

来源：Advanced Materials, 2015, 27(34): 5034-+.

DOI：10.1002/adma.201501502

• MESOPOROUS SILICA NANOPARTICLES
• DRUG-DELIVERY
• IN-VIVO
• MATRIX METALLOPROTEINASES
• TARGETED DELIVERY
• LIPOSOMAL SYSTEM
• RELEASE
• EFFICACY
• NANOCAPSULES
• CELLS

Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.

• 出版日期2015-9-9
• 单位国家纳米科学中心; 中国海洋大学