A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation

作者：Menet Jerome S; Ro**ash Michael^*

来源：Molecular Cell, 2011, 43(5): 695-697.

DOI：10.1016/j.molcel.2011.08.015

Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces a conformational change, which can account for its temporally gated degradation.

• 出版日期2011-9-2