Augmenting antidepressant medication with modular CBT for geriatric generalized anxiety disorder: a pilot study

作者：Wetherell Julie Loebach^*; Stoddard Jill A; White Kamila S; Kornblith Sander; Hoang Nguyen; Andreescu Carmen; Zisook Sidney; Lenze Eric J

来源：International Journal of Geriatric Psychiatry, 2011, 26(8): 869-875.

DOI：10.1002/gps.2619

• aged
• elderly
• cognitive therapy
• behavior therapy
• drug therapy
• psychotherapy
• selective serotonin reuptake inhibitor

Objective: Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in older adults with deleterious effects on health and cognition. Although selective serotonin reuptake inhibitor (SSRI) medications have some efficacy as acute treatments for geriatric GAD, incomplete response is the most common outcome of monotherapy. We therefore developed a novel sequential treatment strategy, using personalized, modular cognitive-behavioral therapy (mCBT) to augment SSRI medication.
Method: In an open label pilot study (N = 10), subjects received a sequenced trial of 12 weeks of escitalopram followed by 16 weeks of escitalopram augmented with mCBT. We also examined the maintenance effects of mCBT over a 28-week follow-up period following drug discontinuation and termination of psychotherapy.
Results: Results suggest that (1) adding mCBT to escitalopram significantly reduced anxiety symptoms and pathological worry, resulting in full remission for most patients and (2) some patients maintained response after all treatments were withdrawn.
Conclusion: Findings suggest that mCBT may be an effective augmentation strategy when added to SSRI medication and provide limited support for the long-term benefit of mCBT after discontinuation of pharmacotherapy.

• 出版日期2011-8