Association of TNFSF8 Polymorphisms With Peripheral Neutrophil Count

作者：Arruda Olson Adelaide M; Roger Veronique L; Chai High S; de Andrade Mariza; Fridley Brooke L; Cunningham Julie M; Gabriel Sherine E; Bielinski Suzette J^*

来源：Mayo Clinic Proceedings, 2011, 86(11): 1075-1081.

DOI：10.4065/mcp.2011.0275

OBJECTIVE: To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interieukin 6 families with neutrophil count.
PATIENTS AND METHODS: Four hundred cases with heart failure after myocardial Infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls.
RESULTS: We found significant associations between the TNFSF8 polymorphisms rs927374 (P=5.1 x 10(-5)) and rs2295800 (P=1.3 x 10(-4)) and neutrophil count; these single-nucleotide polymorphisms are in high linkage dlsequilibrium (r(2)=0.97). Associations persisted after controlling for clinical characteristics and were unchanged after adjusting for case-control status. For rs927374, the neutrophil count of GG homozygotes (7.6 +/- 5.1) was 16% lower than that of CC homozygotes (9.0 +/- 5.2).
CONCLUSION: The TNFSF8 poiymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated. Mayo Clin Proc. 2011;86(11):1075-1081

• 出版日期2011-11