Aflatoxin exposure during the first 1000 days of life in rural South Asia assessed by aflatoxin B-1-lysine albumin biomarkers

作者：Groopman John D^*; Egner Patricia A; Schulze Kerry J; Wu Lee S F; Merrill Rebecca; Mehra Sucheta; Shamim Abu A; Ali Hasmot; Shaikh Saijuddin; Gernand Alison; Khatry Subarna K; LeClerq Steven C; West Keith P Jr; Christian Parul

来源：Food and Chemical Toxicology, 2014, 74: 184-189.

DOI：10.1016/j.fct.2014.09.016

• Aflatoxin
• Aflatoxin B-1-lysine albumin biomarkers
• Child health
• Maternal exposure

Aflatoxin B-1 is a potent carcinogen, occurring from mold growth that contaminates staple grains in hot, humid environments. In this investigation, aflatoxin B-1-lysine albumin biomarkers were measured by mass spectrometry in rural South Asian women, during the first and third trimester of pregnancy, and their children at birth and at two years of age. These subjects participated in randomized community trials of antenatal micronutrient supplementation in Sarlahi District, southern Nepal and Gaibandha District in northwestern Bangladesh. Findings from the Nepal samples demonstrated exposure to aflatoxin, with 94% detectable samples ranging from 0.45 to 2939.30 pg aflatoxin B-1-lysine/mg albumin during pregnancy. In the Bangladesh samples the range was 1.56 to 63.22 pg aflatoxin B-1-lysine/mg albumin in the first trimester, 3.37 to 72.8 pg aflatoxin B-1-lysine/mg albumin in the third trimester, 4.62 to 76.69 pg aflatoxin B-1-lysine/mg albumin at birth and 3.88 to 81.44 pg aflatoxin B-1-lysine/mg albumin at age two years. Aflatoxin B-1-lysine adducts in cord blood samples demonstrated that the fetus had the capacity to convert aflatoxin into toxicologically active compounds and the detection in the same 2-year-old children illustrates exposure over the first 1000 days of life.

• 出版日期2014-12