A New Antifungal Cyclic Lipopeptide from Bacillus marinus B-9987

作者：Liu, Rong-Feng; Zhang, Dao-Jing^*; Li, Yuan-Guang; Tao, Li-Ming; Tian, Li

来源：Helvetica Chimica Acta, 2010, 93(12): 2419-2425.

DOI：10.1002/hlca.201000094

• SUBTILIS
• SURFACTIN
• ITURINS

A new cyclic lipopeptide, marihysin A (1), along with the three known cyclodipeptides cyclo(Ala-Ile) (2), cyclo(Ala-Leu) (3), and cyclo(Ala-Tyr) (4), was isolated from the fermentation broth of the marine microorganism Bacillus marinus B-9987 isolated from the tissues of rhizophere of Suaeda salsa in the intertidal zone of the Bohai Bay of P. R. China. Marihysin A (1) was established to be cyclo(Pro-Gln-Asn(1)-Ser-Asn(2)-Tyr-Asn(3)-beta-aminotetradecanoic acid) by spectroscopic analysis, and it exhibits broad-spectrum but low activity against plant pathogens as determined by antifungal bioassay.

• 出版日期2010
• 单位生物反应器工程国家重点实验室; 华东理工大学; 国家海洋局第一海洋研究所