Drastic Therapy for Listerial Brain Abscess Involving Combined Hyperbaric Oxygen Therapy and Antimicrobial Agents

作者：Nakahara Keiichi; Yamashita Satoshi^*; Ideo Katsumasa; Shindo Seigo; Suga Tomohiro; Ueda Akihiko; Honda Shoji; Hirahara Tomoo; Watanabe Masaki; Yamashita Taro; Maeda Yasushi; Yonemochi Yasuhiro; Takita Tomohiro; Ando Yukio

来源：Journal of Clinical Neurology, 2014, 10(4): 358-362.

DOI：10.3988/jcn.2014.10.4.358

• brain abscess
• Listeria monocytogenes
• subtentorial lesions
• surgical drainage
• hyperbaric oxygen therapy
• antimicrobial agents

Background Listeria monocytogenes (L. monocytogenes) is a rare causative pathogen of brain abscess that is often found in immunocompromised patients. Although patients with supratentorial listerial abscesses showed a longer survival with surgical drainage, the standard therapy for patients with subtentorial lesions has not been established. %26lt;br%26gt;Case Report We report herein a patient with supra- and subtentorial brain abscesses caused by L. rnonocytogenes infection. These abscesses did not respond to antibiotics, and his symptoms gradually worsened. Drainage was not indicated for subtentorial lesions, and the patient was additionally treated with hyperbaric oxygen therapy, which dramatically reduced the volume of abscesses and improved the symptoms. %26lt;br%26gt;Conclusions This is the first report of drastic therapy for a patient with listerial brain abscesses involving combined antibiotics and hyperbaric oxygen therapy. The findings suggest that hyperbaric oxygen therapy is a good option for treating patients with deep-seated listerial abscesses and for who surgical drainage is not indicated.

• 出版日期2014-10