Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

作者：Vinagre Anapaula Sommer^*; Rubio Origuella Roennau Angela Della'Santa; Pereira Sabrina Francisco; da Silveira Lidia Uliano; Wiilland Elenir de Fatima; Suyenaga Edna Sayuri

来源：Brazilian Journal of Pharmaceutical Sciences, 2010, 46(2): 169-177.

• Campomanesia xanthocarpa/pharmacognosy
• Diabetes Mellitus/experimental study
• Hypoglycemic plant
• Histology
• Carbohydrate/metabolism
• Lipid/metabolism

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.

• 出版日期2010-6