Acral Lentiginous Melanoma Incidence and Survival Patterns in the United States, 1986-2005

作者：Bradford Porcia T^*; Goldstein Alisa M; McMaster Mary L; Tucker Margaret A

来源：Archives of Dermatology, 2009, 145(4): 427-434.

Objective: To examine incidence and survival patterns of acral lentiginous melanoma (ALM) in the United States.
Design: Population-based registry study. Weused the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute to evaluate data from 17 population-based cancer registries from 1986 to 2005.
Participants: A total 1413 subjects with histologically confirmed cases of ALM.
Main Outcome Measure: Incidence and survival patterns of patients with ALM.
Results: The age-adjusted incidence rate of ALM overall was 1.8 per million person-years. The proportion of ALMamong all melanoma subtypes was greatest in blacks (36%). Acral lentiginous melanoma had 5-and 10-year melanoma-specific survival rates of 80.3% and 67.5%, respectively, which were less than those for all cutaneous malignant melanomas overall (91.3% and 87.5%, respectively; P <.001). The ALM 5-and 10-year melanomaspecific survival rates were highest in non-Hispanic whites (82.6% and 69.4%), intermediate in blacks (77.2% and 71.5%), and lowest in Hispanic whites (72.8% and 57.3%) and Asian/Pacific Islanders (70.2% and 54.1%). Acral lentiginous melanoma thickness and stage correlated with survival according to sex and in the different racial groups.
Conclusions: Population-based data showed that ALM is a rare melanoma subtype, although its proportion among all melanomas is higher in people of color. It is associated with a worse prognosis than cutaneous malignant melanoma overall. Hispanic whites and Asian/Pacific Islanders have worse survival rates than other groups, and factors such as increased tumor thickness and more advanced stage at presentation are the most likely explanations.

• 出版日期2009-4