Genetic Polymorphism of Manganese Superoxide Dismutase is Associated with Childhood Asthma

作者：Chou Tsai Nung Kuo; Li Ying Shiuan; Lue Ko Huang; Liao Che Feng; Lin Chien Yu; Tzeng Pei Rung; Wong Ruey Hong^*

来源：Journal of Asthma, 2010, 47(5): 532-538.

DOI：10.3109/02770901003686472

• allergen
• CD14
• childhood asthma
• environmental tobacco smoke
• MnSOD
• MPO

Objective. Cellular defenses against allergens and reactive oxygen species (ROS) exposure are critical in the pathogenesis of asthma. CD14 is a receptor for various bacterial products, such as lipopolysaccharides (LPS), and is also a mediator of inflammatory processes. Manganese superoxide dismutase (MnSOD) is an ROS scavenger, and myeloperoxidase (MPO) can convert hydrogen peroxide into hypochlorous acid; thus, they are considered to be involved in inflammatory defense. The authors conducted a case-control study to evaluate the susceptibility to childhood asthma based on CD14, MnSOD, and MPO genes. Methods. The CD14 - 260, MnSOD - 9, and MPO - 463 genotypes were identified by polymerase chain reactions for 116 asthmatic children and 232 healthy controls. Questionnaires were administered to obtain demographic characteristics. Allergen testing used common Taiwanese aeroallergens. Results. A higher level of parental education, family history of asthma, incense burning at home, allergen-test positive, and the MnSOD Val-Ala/Ala-Ala genotypes (matched relative risk = 2.0; 95% confidence interval = 1.0-4.2) were significantly associated with childhood asthma. Interactions between CD14, MnSOD, MPO genotypes and allergy status were significantly associated with asthma risk in these children (all p < .001). Furthermore, atopic cases with MnSOD Val-Ala/Ala-Ala (log eosinophil 2.66/mm(3), log total serum immunoglobulin E [IgE] 2.48 IU/ml) or Val-Val (log eosinophil 2.61/mm(3), log total serum IgE 2.63 IU/ml) genotypes had elevated eosinophil counts and total serum IgE levels as compared to nonatopic cases with MnSOD Val-Val genotype (log eosinophil 2.27/mm(3), log total serum IgE 1.83 IU/ml). Conclusions. Susceptible MnSOD genotypes might modulate the development of asthma in Taiwanese children.

• 出版日期2010-6
• 单位河北医科大学