Neurobiology of depression as a comorbidity of epilepsy

作者：Sankar Raman^*; Mazarati Andrey

来源：Epilepsia, 2010, 51: 81-81.

DOI：10.1111/j.1528-1167.2010.02867.x

• Animal models
• Glucocorticoids
• Hypothalamus-pituitary-adrenal (HPA) axis
• Interleukin-1 beta
• Seizures
• Serotonin

P>The study of depression as a comorbidity of epilepsy in humans is limited by the attendant iatrogenic and psychosocial variables. In order to study the neurobiology of this clinically important phenomenon without the above-mentioned confounding factors, we have studied the behavioral and biochemical correlates of epilepsy-associated depression in two rodent models of limbic epileptogenesis. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).

• 出版日期2010-12