Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor beta 1 gene

作者：Chang S J^*; Chen C J; Tsai F C; Lai H M; Tsai P C; Tsai M H; Ko Y C

来源：Rheumatology, 2008, 47(5): 617-621.

DOI：10.1093/rheumatology/ken054

• tophus
• TGF
• gout
• polymorphism

Objectives. To investigate the associations between gout tophus and polymorphisms 869T/C and -509C/T in TGF-beta 1 gene.
Methods. The polymorphisms 869T/C and -509C/T were determined in 73 gout patients and 114 healthy controls among male Taiwanese using the PCRrestriction fragment length polymorphism method. Each patient was matched with 12 controls by age within 12 yrs. The tophus number was measured from all the patients arms and legs.
Results. Neither 869T/C nor -509C/T showed a significant association between patients and controls in the proportions of genotypes, allele frequency or dominant and recessive models. The mean number of tophi for all patients was 1.53 +/- 3.44, showing a significant difference in distribution among the genotypes at polymorphism 869T/C (P = 0.006), but not those in polymorphism -509C/T (P > 0.05). Those carrying genotype CC at polymorphism 869T/C have a mean number of tophi 0.35 (+/- 1.11), which is significantly lower than those carrying genotype TT (3.73 +/- 4.67; P < 0.05). Those with genotype TT at polymorphism 869T/C also had 11.06 times the likelihood of having at least one tophus compared with the genotype CC after adjustment of hyperuricaemia (95% CI = 1.84, 66.36; P = 0.009). However, except for the tophus number, these two polymorphisms did not show any significant association with the clinical characteristics or biochemical markers.
Conclusions. The polymorphism 869T/C in TGF-beta 1 gene has a significant association with the occurrence of tophus in gout patients.

• 出版日期2008-5
• 单位河北医科大学; 长春大学