Atypical prefrontal cortical responses to joint/non-joint attention in children with autism spectrum disorder (ASD): A functional near-infrared spectroscopy study

作者：Zhu, Huilin^*; Li, Jun; Fan, Yuebo; Li, Xinge; Huang, Dan; He, Sailing

来源：Biomedical Optics Express, 2015, 6(3): 690-701.

DOI：10.1364/BOE.6.000690

• Autism spectrum disorders
• Children with autisms
• Developmental disorders
• Functional connectivity
• Functional connectivity patterns
• Functional near infrared spectroscopy
• Functional near-infrared spectroscopy (fnirs)
• Prefrontal cortex

Autism spectrum disorder (ASD) is a neuro-developmental disorder, characterized by impairments in one's capacity for joint attention. In this study, functional near-infrared spectroscopy (fNIRS) was applied to study the differences in activation and functional connectivity in the prefrontal cortex between children with autism spectrum disorder (ASD) and typically developing (TD) children. 21 ASD and 20 TD children were recruited to perform joint and non-joint attention tasks. Compared with TD children, children with ASD showed reduced activation and atypical functional connectivity pattern in the prefrontal cortex during joint attention. The atypical development of left prefrontal cortex might play an important role in social cognition defects of children with ASD.

• 出版日期2015
• 单位华南师范大学