An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children

作者：Kose Osman^*; Ozmen Ibrahim; Arca Ercan

来源：Journal of Dermatological Treatment, 2013, 24(4): 300-304.

DOI：10.3109/09546634.2011.649690

• viral infection
• childhood
• therapy
• molluscum contagiosum

Objectives: To evaluate and compare the safety and efficacy of 10% potassium hydroxide (KOH) solution and salicylic and lactic acid (SAL + LAC) combination in the treatment of molluscum contagiosum (MC). Material and methods: 26 patients with MC randomized into two treatment groups. 12 patients treated with 10% KOH solution and 14 patients treated with SAL + LAC combination for 6 weeks. Parents of patients were instructed to apply medication once daily only to lesions at study onset. Assessment of response of the treated lesions and side effects was performed at 2, 4 and 6 weeks of the treatment. Newly acquired lesions were not included in the study. Results: At the end of therapy, 83.3% (n = 10) of KOH group demonstrated complete remission and 16.7% (n = 2) ofthem showed partial remission; four patients (33%) developed new lesions during the study. All the patients in the SAL + LAC combination group (100%) demonstrated complete remission of study entry lesions at the end of 6 weeks with five patients (35%) acquiring new lesions during the study. Minor side effects were observed in two groups. Conclusions: 10% KOH solution and SAL + LAC combination were found to be equally effective in the treatment of MC in children.

• 出版日期2013-8
• 单位中国人民解放军军事医学科学院