Development of a novel handheld intra-operative laparoscopic Compton camera for F-18-Fluoro-2-deoxy-2-D-glucose-guided surgery

作者：Nakamura Y^*; Shimazoe K; Takahashi H; Yoshimura S; Seto Y; Kato S; Takahashi M; Momose T

来源：Physics in Medicine and Biology, 2016, 61(15): 5837-5850.

DOI：10.1088/0031-9155/61/15/5837

• radio guided surgery
• FDG
• Compton camera
• MPPC

As well as pre-operative roadmapping by F-18-Fluoro-2-deoxy-2-D-glucose (FDG) positron emission tomography, intra-operative localization of the tracer is important to identify local margins for less-invasive surgery, especially FDG-guided surgery. The objective of this paper is to develop a laparoscopic Compton camera and system aimed at use for intra-operative FDG imaging for accurate and less-invasive dissections. The laparoscopic Compton camera consists of four layers of a 12-pixel cross-shaped array of GFAG crystals (2x2x3 mm(3)) and through silicon via multi-pixel photon counters and dedicated individual readout electronics based on a dynamic time-over-threshold method. Experimental results yielded a spatial resolution of 4 mm (FWHM) for a 10 mm working distance and an absolute detection efficiency of 0.11 cps kBq(-1), corresponding to an intrinsic detection efficiency of similar to 0.18%. In an experiment using a NEMA-like well-shaped FDG phantom, a phi 5x10 mm cylindrical hot spot was clearly obtained even in the presence of a background distribution surrounding the Compton camera and the hot spot. We successfully obtained reconstructed images of a resected lymph node and primary tumor ex vivo after FDG administration to a patient having esophageal cancer. These performance characteristics indicate a new possibility of FDG-directed surgery by using a Compton camera intra-operatively.

• 出版日期2016-8-7