Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity

作者：Malyarenko Timofey V; Kicha Alla A; Ivanchina Natalia V; Kalinovsky Anatoly I; Popov Roman S; Vishchuk Olesya S; Stonik Valentin A^*

来源：Steroids, 2014, 87: 119-127.

DOI：10.1016/j.steroids.2014.05.027

• Asterosaponins
• Starfish
• Leptasterias ochotensis
• Cytotoxicity
• Clonogenic assay

Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.

• 出版日期2014-9