A novel biomarker for prediction of atrial fibrillation susceptibility in patients with celiac disease

作者:Kucukseymen Selcuk*; Cekin Ayhan Hilmi; Bayar Nermin; Arslan Sakir; Kucukseymen Elif Uygur; Mercan Tanju; Ozdemir Semir
来源:PLos One, 2018, 13(1): e0190382.
DOI:10.1371/journal.pone.0190382

摘要

Background
Celiac disease (CD), a serious autoimmune disorder that occurs in people who are genetically predisposed, is induced by dietary gluten intake and affects primarily the small intestine. Many studies have identified an increased risk of cardiovascular problems in patients with CD. Moreover, these patients are susceptible to certain liver diseases, as well as fibrosis.
Objective
The aim of this study was to assess the presence of fibrosis using the De Ritis ratio, determining its effect on the electromechanical features of the left atrium and its susceptibility to atrial fibrillation (AF) in patients with CD.
Methods
A total of 97 patients diagnosed with CD by antibody test and biopsy were included in this prospective study. Two groups were created from these patients, a fibrosis-prone (FP) group and a non-fibrosis-prone (NFP) group, according to the cut-off value, as defined in previously published reports, for the AST/ALT ratio. Electrocardiographic and echocardio-graphic examinations were performed as part of the study.
Results
There were no differences in the baseline characteristics and conventional echocardio-graphic parameters of the defined groups. However, the patients in the FP group, as compared to those in the NFP group, had significantly increased PWD (56.68 +/- 6.48 ms vs. 37.49 +/- 6.22 ms, P<0.001). Additionally, significantly higher interatrial (60.50 +/- 13.05 ms vs. 29.40 +/- 11.55 ms, P<0.001), intra-left atrial (44.18 +/- 14.12 ms vs. 21.02 +/- 11.99 ms, P<0.001), andintra-right atrial (15.61 +/- 8.91 ms vs. 8.38 +/- 4.50 ms, P<0.001) EMD was found among the patients in the FP group compared to that of the NFP group.
Conclusion
It is believed that the susceptibility to AF cited in previous studies may be related to fibrosis. Our study is the first to examine the possible effects of fibrosis on AF susceptibility in patients with CD, whereby we propose a new biomarker for prediction of AF susceptibility of these patients.

  • 出版日期2018-1-9