Mechanisms of current therapies for diabetes mellitus type 2

作者：Thule Peter M^*

来源：Advances in Physiology Education, 2012, 36(4): 275-283.

DOI：10.1152/advan.00094.2012

• diabetes mellitus
• oral agents
• glucagon-like peptide-1 agonists
• dipeptidyl peptidase-4 inhibitors
• metformin

Thule PM. Mechanisms of current therapies for diabetes mellitus type 2. Adv Physiol Educ 36: 275-283, 2012; doi:10.1152/advan.00094.2012.-The array of medications available for the treatment of hyperglycemia has increased rapidly in the previous decade, and recent investigations have clarified novel mechanisms underlying the antihyperglycemic efficacy of these drugs. This article reviews the mechanisms of action for medications currently approved to treat diabetes mellitus in the United States, with the exception of insulin and its analogs. Finally, it attempts to integrate these mechanisms into the schema of pathophysiological factors that combine to produce hyperglycemia in patients with diabetes mellitus.

• 出版日期2012-12