A study of the distribution of phylogenetically conserved blocks within clusters of mammalian homeobox genes

作者：Stojanovic Nikola^*

来源：Genetics and Molecular Biology, 2009, 32(3): 666-673.

DOI：10.1590/s1415-47572009000300034

• genomics
• phylogenetic conservation
• multiple sequence alignments
• heaviest segments
• Hox

Genome sequencing efforts of the last decade have produced a large amount of data, which has enabled whole-genome comparative analyses in order to locate potentially functional elements and study the overall patterns of phylogenetic conservation. In this paper we present a statistically based method for the characterization of these patterns in mammalian DNA sequences. We have applied this approach to the study of exceptionally well conserved homeobox gene clusters (Hox), based on an alignment of six species, and we have constructed a map of Hox cataloguing the conserved fragments, along with their locations in relation to the genes and other landmarks, sometimes showing unexpected layouts.

• 出版日期2009