Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

作者：Couette Maryline; Boisse Marie Francoise; Maison Patrick; Brugieres Pierre; Cesaro Pierre; Chevalier Xavier; Gherardi Romain K; Bachoud Levi Anne Catherine; Authier Francois Jerome^*

来源：Journal of Inorganic Biochemistry, 2009, 103(11): 1571-1578.

DOI：10.1016/j.jinorgbio.2009.08.005

• Aluminum
• Macrophagic myofasciitis
• Vaccine
• Cognitive dysfunction
• Myopathy

Macrophagic myofasciitis (MMF) is an emerging condition, characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients mainly complain of arthromyalgias, chronic fatigue, and cognitive difficulties. We designed a comprehensive battery of neuropsychological tests to prospectively delineate MMF-associated cognitive dysMACD). Compared to control patients with arthritis and chronic pain, MMF patients had pronounced and specific cognitive impairment. MACD mainly affected (i) both visual and verbal memory; (ii) executive functions, including attention, working memory, and planning; and (iii) left ear extinction at dichotic listening test. Cognitive deficits did not correlate with pain, fatigue, depression, or disease duration. Pathophysiological mechanisms underlying MACD remain to be determined. In conclusion, long-term persistence of vaccine-derived aluminum hydroxide within the body assessed by MMF is associated with cognitive dysfunction, not solely due to chronic pain, fatigue and depression.

• 出版日期2009-11