Disease severity, scratching, and sleep quality in patients with atopic dermatitis

作者：Bender Bruce G^*; Ballard Robert; Canono Beth; Murphy James R; Leung Donald Y M

来源：Journal of the American Academy of Dermatology, 2008, 58(3): 415-420.

DOI：10.1016/j.jaad.2007.10.010

Background: The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined.
Methods: Sleep efficiency and scratching were measured over 2 nights by polysomnography, actigraphy, and self-report in 20 adults with atopic dermatitis. Tumor necrosis factor, interleukin (IL)-6, and IL-10 were assayed from a subset of 9 participants.
Results: Sleep measured by actigraphy and polysomnography were strongly associated with each other. Decreased sleep efficiency was associated with increasing disease severity, scratching, and IL-6. Self-reported sleep quality and quality of life were not significantly correlated with either objective sleep measure.
Limitations: Results in this pilot study await confirmation in a larger investigation.
Conclusion: Objective measures but not self-report documented that increasing severity of atopic dermatitis results in more scratching and declining sleep quality. Our data also suggest an important relationship between sleep and IL-6.

• 出版日期2008-3