A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in Golden Syrian hamsters

作者：Lamirande Elaine W; DeDiego Marta L; Roberts Anjeanette; Jackson Jadon P; Alvarez Enrique; Sheahan Tim; Shieh Wun Ju; Zaki Sherif R; Baric Ralph; Enjuanes Luis; Subbarao Kanta^*

来源：Journal of Virology, 2008, 82(15): 7721-7724.

DOI：10.1128/JVI.00304-08

The immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-Delta E) were studied using hamsters. Hamsters immunized with rSARS-CoV-Delta E developed high serum-neutralizing antibody titers and were protected from replication of homologous (SARS-CoV Urbani) and heterologous (GD03) SARS-CoV in the upper and lower respiratory tract. rSARS-CoV-Delta E-immunized hamsters remained active following wildtype virus challenge, while mock-immunized hamsters displayed decreased activity. Despite being attenuated in replication in the respiratory tract, rSARS-CoV-Delta E is an immunogenic and efficacious vaccine in hamsters.

• 出版日期2008-8