科研之友
微信
新浪微博
Facebook
分享链接
摘要
The purpose of this study was to investigate the potential pharmacokinetic advantage of pancreatic arterial infusion chemotherapy with lipid emulsion as a drug carrier for pancreatic cancer in a dog model. The 20% Intralipid, as a solvent, was used in the experimental animals with 2 ml/kg (group A) and 1 ml/kg (group B). Normal sodium as a solvent was used as a control with 2 ml/kg (group C) and 1 ml/kg (group D), respectively. Cisplatin (4 mg/kg) was infused into the proximal segment of the splenic artery. The concentrations of cisplatin were measured in plasma of the portal vein and in the liver and pancreas of groups A and C. The area under the concentration-time curve (AUC), the maximum plasma concentration (C-max), and the elimination half-life (t(1/2)) in plasma were calculated and compared statistically. Compared with group C, the AUC and C-max of group A were significantly lower (P < 0.01 and P < 0.01, respectively), the t(1/2) was longer (P < 0.05), and the tissue cisplatin concentration of the pancreas was higher (P < 0.05). Compared with group D, the AUC and C-max of group B were significantly lower (P < 0.01 and P < 0.01, respectively) and the t(1/2) was longer (P < 0.01). Pancreatic arterial infusion chemotherapy with lipid emulsion as a drug carrier can increase the local concentration and prolong the retention time of a drug.
- 出版日期2012-8
- 单位中国人民解放军总医院; 中国人民解放军第三〇九医院
