Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells

作者：Khan Shaukat Ali; Nowatzky Johannes; Jimenez Branda Sonia; Greenberg Jeffrey David; Clancy Robert; Buyon Jill; Bhardwaj Nina^*

来源：Experimental and Molecular Pathology, 2013, 95(2): 121-123.

DOI：10.1016/j.yexmp.2013.06.003

• Systemic lupus erythematosus
• Dendritic cells
• Disease activity
• Autoimmunity

Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.
Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI >= 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation.
Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality.
Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.

• 出版日期2013-10