A novel electrochemical biomimetic sensor based on poly(Cu-AMT) with reduced graphene oxide for ultrasensitive detection of dopamine

作者：Li, Yaru; Gu, Yue; Zheng, Bo; Luo, Lan; Li, Cong; Yan, Xiaoyi; Zhang, Tingting; Lu, Nannan; Zhang, Zhiquan^*

来源：Talanta, 2017, 162: 80-89.

DOI：10.1016/j.talanta.2016.10.016

• Biomimetic sensor
• Reduced graphene oxide
• Copper
• Electrochemistry
• Dopamine

A polymerized film of copper-2-amino-5-mercapto-1,3,4-thiadiazole (Cu(II)-AMT) complex (poly(Cu-AMT)) was successfully achieved via a simple and low-cost electrochemical methodology. Subsequently, a noncovalent nanohybrid of poly(Cu-AMT) with reduced graphene oxide (rGO) (rGO-poly(Cu-AMT)) was prepared through pi-pi stacking interaction as an efficient mimetic enzyme for the ultrasensitive and selective detection of dopamine (DA). The rGO-poly(Cu-AMT) nanocomposites showed considerable mimetic enzyme catalytic activity, which may be attributed to the significant promotion of the electron transfer between the substrate and graphene-based carbon materials, and also the synergistic electrocatalytic effect in mimetic enzyme between rGO sheet and poly(Cu-AMT). The electrocatalytic and sensing performances of the biomimetic sensor based on the rGO-poly(Cu-AMT) nanocomposites were evaluated in detail. The biomimetic sensor enables a reliable and sensitive determination of DA with a linear range of 0.01-40 mu M and a detection limit of 3.48 nM at a signal-to-noise ratio of 3. In addition, we applied the proposed method to detect DA in real sample with satisfactory results. Accordingly, the rGO-poly(Cu-AMT) is one of the. promising mimetic enzyme for electrocatalysis and biosensing.

• 出版日期2017-1-1
• 单位吉林大学