A Decrease in Spatially Resolved Near-Infrared Spectroscopy-Determined Frontal Lobe Tissue Oxygenation by

作者：Ogoh Shigehiko^*; Sato Kohei; Okazaki Kazunobu; Miyamoto Tadayoshi; Secher Frederik; Sorensen Henrik; Rasmussen Peter; Secher Niels H

来源：Anesthesia and Analgesia, 2014, 118(4): 823-829.

DOI：10.1213/ANE.0000000000000145

BACKGROUND: Spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation (Sco(2)) is reduced with administration of phenylephrine, while cerebral blood flow may remain unaffected. We hypothesized that extracranial vasoconstriction explains the effect of phenylephrine on Sco(2). %26lt;br%26gt;METHODS: We measured Sco(2) and internal and external carotid as well as vertebral artery blood flow in 7 volunteers (25 [SD 4] years) by duplex ultrasonography during IV infusion of phenylephrine, together with middle cerebral artery mean blood velocity, forehead skin blood flow, and mean arterial blood pressure. %26lt;br%26gt;RESULTS: During phenylephrine infusion, mean arterial blood pressure increased, while Sco(2) decreased by -19% 3% (mean +/- SE; P = 0.0005). External carotid artery (-27.5% +/- 3.0%) and skin blood flow (-25.4% +/- 7.8%) decreased in response to phenylephrine administration, and there was a relationship between Sco(2) and forehead skin blood flow (Pearson r = 0.55, P = 0.042, 95% confidence interval [CI], = 0.025-0.84; Spearman r = 0.81, P %26lt; 0.001, 95% CI, 0.49-0.94) and external carotid artery conductance (Pearson r = 0.62, P = 0.019, 95% CI, 0.13 to 0.86; Spearman r = 0.64, P = 0.012, 95% CI, 0.17-0.88). %26lt;br%26gt;CONCLUSIONS: These findings suggest that a phenylephrine-induced decrease in Sco(2), as determined by INVOS-4100 near-infrared spectroscopy, reflects vasoconstriction in the extracranial vasculature rather than a decrease in cerebral oxygenation.

• 出版日期2014-4