Bortezomib with Thalidomide plus Dexamethasone Compared with Thalidomide plus Doxorubicin and Dexamethasone as Induction Therapy in Previously Untreated Multiple Myeloma Patients

作者：Buda Gabriele^*; Orciuolo Enrico; Carulli Giovanni; Galimberti Sara; Ghio Francesco; Cervetti Giulia; Pelosini Matteo; Petrini Mario

来源：Acta Haematologica, 2013, 129(1): 35-39.

DOI：10.1159/000339635

• Bone marrow transplant
• Multiple myeloma
• Thalidomide, bortezomib and dexamethasone
• Thalidomide plus doxorubicin and dexamethasone

We conducted a retrospective study to compare thalidomide, bortezomib and dexamethasone (VTD) with thalidomide plus doxorubicin and dexamethasone (TAD). Until now, first-line treatment with these combinations has not been reported in any comparative study. The principal objective of this study was to determine whether VTD would improve the complete response (CR) and CR plus very good partial response rates compared with TAD. Second, using additional methods, such as flow cytometric assays and polymerase chain reaction technology, we evaluated the molecular residual disease in the subgroup of patients that obtained CR. Our study shows that VTD is a superior induction regimen compared with TAD, with a higher response rate after induction, translating into greater CR plus very good partial response.

• 出版日期2013