Atypical tumor regression

作者：Heitplatz B^*; Mueller K M

来源：Pathologe, 2013, 34(6): 566-568.

DOI：10.1007/s00292-013-1854-2

• Immunohistology
• Cell alterations
• Radiochemotherapy
• Methotrexate
• Cellular necrosis pattern

A 67-year-old man presented with a poorly differentiated squamous cell carcinoma of the esophagus diagnosed by biopsy. After neoadjuvant radiochemotherapy the gastroesophagectomy specimen showed diffuse polymorphic and anuclear cell residues ranging from 35 A mu m to 46 A mu m in size. Immunohistochemically, PanCK and AE1-3 revealed a positive staining while CD68 and MIB1 showed a negative staining. %26lt;br%26gt;The retrospective anamnesis revealed that the patient had chronic polyarthritis as underlying illness, for which reason he had been taking humira and methotrexate, a cytostatic drug, for many years. Therefore, the development of the tumor might have been enhanced by these drugs. Electron microscopic analysis confirmed that the avital akaryote cell residues represented a special type of tumor regression. Complete tumor regression level IV without vital rest tumor tissue based on Baldus et al. was diagnosed.

• 出版日期2013-11