Antibacterial, Yeast and Fungal Polymeric Materials Derived from Organotin-Containing Materials

作者：Carraher Charles E Jr^*; Naoshima Yoshinobu; Nagao Kazutaka; Roner Michael R; Zhao Anna; Barot Girish; Battin Amitabh

来源：Journal of Polymer Materials, 2011, 28(3): 303-336.

• Organotin compounds
• organotin polymers
• bacteria
• antibacterial agents
• antimicrobial agents
• dibutyltin dichloride
• polymeric drugs
• fungicides
• bactericides

Organotin compounds have been commercially employed to inhibit bacteria and fungi for over 50 years. While much of the earlier work had been done on small molecule-containing organotins, most of the recent effort has focused on polymers that contain organotin moieties. This paper reviews recent efforts to inhibit a wide range of bacteria and fungi by our group. It also offers background on bacteria, organotin biological activity, and the variety of organotins employed to inhibit bacteria. The results are consistent with some of these polymers being candidates for further study as solid additives to formulations where inhibition is desired. Four items are of particular interest. First, is the ability of the water soluble polymers to inhibit the growth of most of the test organisms making them particularly desirable candidates as additives where soluble materials can be used such as in water-born coatings. Second, the ability of the PGH-containing polymers to inhibit most of the test organisms increases the desirability of using such materials to increase the germination of seeds stored under less than ideal conditions and for extended times. Third, the fact that these materials can be easily and readily made employing a technique already employed industrially from commercially available reactants, contributes to their possible commercial use. Fourth, because some of these materials offer an outstanding wide range of ability to inhibit, they are candidates to be tested against more difficult inhibited microbes including potential "weapons of mass destruction".

• 出版日期2011-9