Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity

作者：Cen Pacheco Francisco; Perez Manriquez Claudia; Luisa Souto Maria; Norte Manuel; Javier Fernandez Jose; Hernandez Daranas Antonio

来源：Marine Drugs, 2018, 16(4): 131.

DOI：10.3390/md16040131

• phosphatase inhibition
• marine polyether
• longilenes
• docking simulation
• red alga
• Laurencia viridis

The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were isolated from this alga, in addition to other substances, 4 and 5, resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide (1) inhibited PP2A (IC50 11.3 mu M). In order to explain the interaction between PP2A and compounds 1 and 3, molecular docking simulations onto the PP2A enzyme-binding region were used.

• 出版日期2018-4