Antimicrobial activity of simplified mimics of celogentin C

作者：Thombare Varsha J; Holden James A; Pal Sreetama; Reynolds Eric C; Chattopadhyay Amitabha; O'Brien Simpson Neil M; Hutton Craig A^*

来源：Tetrahedron, 2018, 74(12): 1288-1293.

DOI：10.1016/j.tet.2017.12.032

• Celogentin
• Antimicrobial peptides
• Stapled peptides
• Cyclic peptides

Linear and bicyclic analogues of the peptide natural product, celogentin C, have been prepared in which the sidechain-sidechain crosslinks in celogentin are omitted or replaced with a mesitylenyl moiety. The simplified bicyclic peptides display moderate antibacterial activity, potentially through inhibition of bacterial protomicrotubule formation, while the linear analogs show higher antibacterial activity through a possible membrane disruption mechanism.

• 出版日期2018-3-22