Diffusion tensor MRI contributes to differentiate Richardson%26apos;s syndrome from PSP-parkinsonism

作者：Agosta Federica; Pievani Michela; Svetel Marina; Lukic Milica Jecmenica; Copetti Massimiliano; Tomic Aleksandra; Scarale Antonio; Longoni Giulia; Comi Giancarlo; Kostic Vladimir S; Filippi Massimo^*

来源：Neurobiology of Aging, 2012, 33(12): 2817-2826.

DOI：10.1016/j.neurobiolaging.2012.02.002

• Richardson%26apos
• s syndrome
• PSP-Parkinsonism
• Diffusion tensor MRI
• Atrophy

This study investigated the regional distribution of white matter (WM) damage in Richardson%26apos;s syndrome (PSP-RS) and progressive supranuclear palsy-Parkinsonism (PSP-P) using diffusion tensor (DT) magnetic resonance imaging (MRI). The DT MRI classificatory ability in diagnosing progressive supranuclear palsy (PSP) syndromes, when used in combination with infratentorial volumetry, was also quantified. In 37 PSP (21 PSP-RS, 16 PSP-P) and 42 controls, the program Tract-Based Spatial Statistics (TBSS; www.fmrib.ox.ac.uk/fsl/tbss) was applied. DT MRI metrics were derived from supratentorial, thalamic, and infratentorial tracts. The magnetic resonance parkinsonism index (MRPI) was calculated. All PSP harbored diffusivity abnormalities in the corpus callosum, frontoparietal, and frontotemporo-occipital tracts. Infratentorial WM and thalamic radiations were severely affected in PSP-RS and relatively spared in PSP-P. When MRPI and DT MRI measures were combined, the discriminatory power increased for each comparison. Distinct patterns of WM alterations occur in PSP-RS and PSP-P. Adding DT MRI measures to MRPI improves the diagnostic accuracy in differentiating each PSP syndrome from healthy individuals and each other.

• 出版日期2012-12