An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered with Infanrix (TM) hexa is immunogenic, with an acceptable safety profile in 12-23-month-old children

作者：Knuf Markus^*; Pantazi Chatzikonstantinou Anna; Pfletschinger Ulrich; Tichmann Schumann Irmingard; Maurer Hartwig; Maurer Lothar; Fischbach Thomas; Zinke Henrike; Pankow Culot Heidemarie; Papaevangelou Vassiliki; Bianco Veronique; Van der Wielen Marie; Miller Jacqueline M

来源：Vaccine, 2011, 29(25): 4264-4273.

DOI：10.1016/j.vaccine.2011.03.009

• Tetravalent meningococcal vaccine
• Conjugate vaccine
• Bactericidal activity
• Hexavalent vaccine
• DTaP-HBV-IPV/Hib combination vaccine

Tetravalent meningococcal serogroups ACWY conjugate vaccines will provide an advantage to those at most risk of invasive meningococcal disease; namely young children. Co-administration of ACWY-TT with DTaP-HBV-IPV/Hib was assessed in a randomized trial in 793 children aged 12-23 months. Pre-specified criteria for non-inferiority of immunogenicity following co-administration versus separate ACWY-TT and DTaP-HBV-IPV/Hib administration were reached. One month post-vaccination, >= 97.3% of ACWY-TT vaccinees had rSBA titres >= 1:8 (all serogroups). Seroprotection/seropositivity rates against DTaP-HBV-IPV/Hib antigens were >= 98.2%. The safety profile of co-administration was similar to that of DTaP-HBV-IPV/Hib alone. ACWY-TT and DTaP-HBV-IPV/Hib co-administration during the second year would facilitate introduction of ACWY-TT into routine toddler vaccination schedules.

• 出版日期2011-6-6