Automatic Model-Based Analysis of Skeletal Muscle BOLD-MRI in Reactive Hyperemia

作者：Schewzow Kiril; Andreas Martin; Moser Ewald; Wolzt Michael; Schmid Albrecht I^*

来源：Journal of Magnetic Resonance Imaging, 2013, 38(4): 963-969.

DOI：10.1002/jmri.23919

• BOLD
• skeletal muscle
• ischemia
• reactive hyperemia
• data analysis

PurposeTo propose a quantitative model for a reliable and operator independent estimation of parameters describing blood oxygen-level dependent (BOLD) MRI time course in calf muscles during reactive hyperemia. %26lt;br%26gt;Materials and MethodsEcho planar imaging-based BOLD-MRI of the human calf were acquired during and after cuff-induced ischemia of the leg. Regions of interest were drawn in soleus, gastrocnemius and tibialis anterior muscles. A gamma-variate plus a sigmoidal function were fitted to the reactive hyperemia time courses and parameters including time to peak (TTP), hyperemic peak value (HPV), peak area, and peak width were calculated. In addition, the TTP and HPV parameters were estimated manually by two operators to validate the reliability of the fitting procedure. %26lt;br%26gt;ResultsThe model function was fitted successfully to all data with a minimum reduced R-2 around 0.9. The in vivo results were in agreement with manually determined values (r 0.69), although significant inter-operator differences were observed. %26lt;br%26gt;ConclusionThe proposed method allows for rapid, operator independent and robust quantification of muscle BOLD signal during reactive hyperemia. The model worked equally well over a wide range of imaging parameters and data quality. This approach should contribute significantly to the standardization of skeletal muscle BOLD-MRI, an important step toward its clinical application. J. Magn. Reson. Imaging 2013;38:963-969.

• 出版日期2013-10