Alcohol increases spontaneous BOLD signal fluctuations in the visual network

作者：Esposito Fabrizio^*; Pignataro Giuseppe; Di Renzo Gianfranco; Spinali Alessandra; Paccone Antonella; Tedeschi Gioacchino; Annunziato Lucio

来源：NeuroImage, 2010, 53(2): 534-543.

DOI：10.1016/j.neuroimage.2010.06.061

• Functional magnetic resonance imaging fMRI
• Resting state
• Independent component analysis
• Visual function
• Visual network
• Visual perception

Brain activity during resting wakefulness is characterized by slow (<0 1 Hz) fluctuations of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals that are topographically organized in discrete functional connectivity networks (resting-state networks, RSNs). The present study aimed at revealing possible network-specific alcohol-Induced changes in resting-state fMRI (RS-fMRI) signals
RS-fMRI was carried out on eight healthy subjects in four consecutive 6-min sessions, one before and three after a 07 g/kg dose of ethyl alcohol Control experiments were carried out in different days without alcohol administration. Independent component analysis (ICA) was performed on all experimental and control scans to extract individual and group-level RSN maps in a dynamic network analysis
Alcohol administration significantly increased the overall strength of the visual network ICA component, reaching the peak at 90 min Within the visual network, the alcohol-induced increase was more pronounced in the primary regions of the occipital cortex and less pronounced in the secondary regions of the occipito-temporal cortex Other major RSN components, such as the default-mode, the fronto-parietal, the sensorimotor, the self-referential and the auditory components, did not exhibit alcohol-induced changes during the same time window
Alcohol-induced effects on the resting-state functional connectivity of the visual network observed in the present study demonstrate that the visual system is a selective and primary target of acute alcohol administration The strong enhancement of spontaneous BOLD

• 出版日期2010-11-1