Analysis of early phase [C-11]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis

作者：Kaneta Tomohiro^*; Okamura Nobuyuki; Arai Akira; Takanami Kentaro; Furukawa Katsutoshi; Tashiro Manabu; Furumoto Shozo; Iwata Ren; Takahashi Shoki; Arai Hiroyuki; Yanai Kazuhiko; Kudo Yukitsuka

来源：Japanese Journal of Radiology, 2014, 32(3): 138-144.

DOI：10.1007/s11604-013-0276-7

• Amyloid imaging
• Early phase
• BF-227
• Alzheimer's disease
• 3D-SSP

To examine the usefulness of the early phase [C-11]BF-227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method.
This study included 20 mild cognitive impairment (MCI), 19 Alzheimer's disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0-10 and 40-60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using F-8-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images.
Method B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC.
The early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.

• 出版日期2014-3